DAXI: All About The Longer-Lasting Botox Alternative

The long-awaited, longer-lasting neuromodulator drug DaxibotulinumtoxinA for injection (DAXI), a botulinum toxin type A formulated with a novel peptide excipient may be nearing US FDA approval.  The studies have shown that DAXI is effective for treating neck spasms (cervical dystonia) and for reducing the appearance of frown lines. While this one is hardly as life-changing, for those of us who use Botox and its counterparts for reducing wrinkles, restraining overactive muscle movement, or controlling sweats, this is pretty exciting.

What is Daxi?

DaxibotulinumtoxinA for Injection (DAXI) is a novel Botulinum toxin type A product containing highly purified 150-kDa core neurotoxin and is the first to be formulated with a proprietary stabilizing excipient peptide (RTP004) instead of human serum albumin. DAXI produces robust, extended efficacy across both aesthetic and therapeutic indications.(1)

Similar to other Botox-like injectables, DAXI works by temporarily paralyzing the facial muscles responsible for causing static lines and wrinkles.  DaxibotulinumtoxinA® for Injection (DAXI) is intended to last longer than the currently available forms of botulinum toxin type A, and is showing promising results in clinical trials.(2)

How long will it last?

Data from the Revance Aesthetics (manufacturer of Daxi)  showed DAXI to be effective for a median duration of 6 months, with baseline wrinkles returning after 28 weeks, which are longer-lasting than the effects of the currently approved botulinum toxin products typically wear off about 3–4 months after injection and so the injections must be repeated regularly.

When will you see the results?

The onset time was 3 days (similar to Botox). Full results typically take 7 to 14 days to appear with botulinum toxin type A products.

Is Daxi safe? 

Daxi is considered to be very safe. Daxi may be safer than other Botox-like products according to the American Board of Cosmetic Surgery for a few reasons:

  • Unlike Botox, Daxi is stable at room temperature and doesn't require refrigeration.

  • Daxi doesn't contain albumin, a blood-derived protein used in other botulinum toxin brands as a stabilizer to protect the neurotoxin complex during manufacturing, shipping, storage, and administration. Albumin carries a very remote risk of viral disease transmission.

Potential Side Effects

The side effects seen with DAXI are consistent in nature and frequency with those seen with other botulinum toxin products. If it is injected in the wrong area, there is a risk of ending up with a drooping eyelid or eyebrow, so it’s important to go to a practitioner who is licensed in administering neurotoxins to ensure correct placement.

Final Takeaway

If you’re familiar with Botox and its counterparts, but often wish you could stretch the time between treatments, DAXI might be a very promising option for you. Also, people with a busy lifestyle who doesn't have time to come in to be treated three to four times a year would be a great candidate for DAXI.