GC-ARGININE Inj.
- Characteristics: Colorless, transparent liquid in a vial for injection
- Full Ingredient:
- 6g of L-Arginine Hydrochloride in 1 vial (10ml)
- 15g of L-Arginine Hydrochloride in 1 vial (25ml)
- Efficacy/Effect:
- Decreases ammonia concentration in cases of acute exacerbation of hyperammonemia due to the following diseases, which cannot be controlled by oral administration
- Congenital urea circuit abnormality
- Carbamyl phosphate synthetase (CPS) deficiency
- Ornithine transcarbamylase (OTC) deficiency
- Arginosuccinate synthetase (ASS) deficiency
- Arginosuccinate lyase (ASL) deficiency
- Lysinuric protein intolerance
- Acidifying agents in severe metabolic alkalosis
- Usage/Dosage:
- Decreases ammonia concentration in cases of acute exacerbation of hyperammonemia. To be used only when control is impossible with oral administration
- Continuous intravenous injection of L-arginine hydrochloride (0.2∼1g per kg of patient body weight) over 1 hour
- Acidifying agents in severe metabolic alkalosis
- Dose of intravenous injection: L-arginine hydrochloride (g) = the amount of decrease to reach in plasma carbonate concentration (mM/L) × [patient's weight (kg)/9.6]
- Pituitary function test to measure growth hormone secretion
- Continuous intravenous injection of L-arginine hydrochloride (500mg per kg of subject body weight, 10% solution) is administered over a 30-minute period
- Diagnosis
- Patient must fast and then go to bed at their normal time. Testing is carried out the next morning
- Have patient lie down for at least 30 minutes before injection
- After injection into the anterior cardinal vein or other appropriate vein, blood is drawn from a vein in the opposite arm
- Blood is drawn 30minutes before the injection, right after the injection, then 30, 60, 90, 120, and 150 minutes after the injection
- Administer the recommended amount for 30 minutes. Keep dosage constant throughout the injection
- The blood drawn before radioimmunoassay is immediately centrifuged and the plasma is stored at -20℃
- Growth hormone deficiency is diagnosed by retesting this drug or an insulin-induced hypoglycemia test
- (Wait 24 hours before retesting)
- Storage: Store in a sealed container at room temperature (1~30℃)
- Packaging Unit: 10ml, 25ml X 10 vials