Multi Supply 5 (Selenium, Zinc, Manganese, Copper, Chromium)

About Supply 5

Indications

Administration of the solution in TPN solutions helps to maintain plasma levels of zinc, copper, manganese, selenium and chromium

Dosage & Administration

Each mL of the solution provides Zinc 1 mg, Copper 0.4 mg, Manganese 0.1 mg, Chromium 4 mcg, and Selenium 20 mcg

The suggested dosage ranges for the five trace elements are

ZINC : For the metabolically stable adult receiving TPN, the suggested intravenous dosage level is 2.5 to 4 mg zinc/day

An additional 2 mg zinc/day is suggested for acute catabolic states

For the stable adult with fluid loss from the small bowel, an additional 12.2 mg zinc/liter of small bowel fluid lost, or an additional 17.1 mg zinc/kg of stool or ileostomy output is recommended

Frequent monitoring of zinc blood levels is suggested for patients receiving more than the usual maintenance dosage level of zinc. Normal plasma levels for zinc vary from approximately 88 to 112 mcg/100 mL. For full term infants and children up to 5 years of age, 100 mcg zinc/kg/day is recommended. For premature infants (birth weight less than 1500 g) up to 3 kg in body weight, 300 mcg zinc/kg/day is suggested

COPPER : For the metabolically stable adult receiving TPN, the suggested additive dosage level is 0.5 to 1.5 mg copper/day

For pediatric patients, the suggested additive dosage level is 20 mcg copper/kg/day

The normal plasma range for copper is approximately 80 to 160 mcg/100 mL

MANGANESE : For the metabolically stable adult receiving TPN, the suggested additive dosage level for manganese is 0.15 mg to 0.8 mg/day

For pediatric patients, a dosage level of 2 to 10 mcg manganese/kg/day is recommended

CHROMIUM : For the metabolically stable adult receiving TPN, the suggested additive dosage level is 10 to 15 mcg chromium/day

The metabolically stable adult with intestinal fluid loss may require 20 mcg chromium/day, with frequent monitoring of blood levels as a guideline for subsequent administration

For pediatric patients, the suggested additive dosage level is 0.14 to 0.20 mcg/kg/day

SELENIUM : For metabolically stable adults receiving TPN, the suggested additive dosage level is 20 to 40 mcg selenium/day

For pediatric patients, the suggested additive dosage level is 3 mcg/kg/day

In adults, selenium deficiency states resulting from long term TPN support, selenium as selenomethionine or selenious acid, administered intravenously at 100 mcg/day for a period of 24 and 31 days, respectively, has been reported to reverse deficiency symptoms without toxicity

The normal whole blood range for selenium is approximately 10 to 37 mcg/100 mL

Periodic monitoring of plasma levels of Zinc, Copper, Manganese, Chromium and Selenium is suggested as a guideline for administration

Storage

Hermetic container, Store at temperatures between 15°C and 30°C

Shelf-life

24 months from the manufacturing date